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Internalization and degradation of hepatocyte growth factor in hepatocytes with down-regulation of the receptor/c-Met

✍ Scribed by Daiji Naka; Takeshi Shimomura; Yoshiko Yoshiyama; Maki Sato; Mutsumi Sato; Takehisa Ishii; Hiroto Hara


Book ID
115927401
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
673 KB
Volume
329
Category
Article
ISSN
0014-5793

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## Abstract The receptor for the hepatocyte growth factor/scatter factor (HGF/SF), c‐Met, plays a role in tumour promotion, progression and metastasis. In this study, we analysed chemically induced hepatocarcinogenesis in mice lacking a functional HGF receptor in their liver. Control and c‐Met defi