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Internal Standard Capillary Electrophoresis as a High-Throughput Method for p K a Determination in Drug Discovery and Development

✍ Scribed by Cabot, Joan M.; Fuguet, Elisabet; Rosés, Martí


Book ID
127212793
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
952 KB
Volume
16
Category
Article
ISSN
2156-8952

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A rapid method for pKa determination of
✍ Yasushi Ishihama; Masahiro Nakamura; Toshinobu Miwa; Takashi Kajima; Naoki Asaka 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 152 KB 👁 1 views

We developed a rapid screening method for determination of pK(a) of candidate drugs by pressure-assisted capillary electrophoresis (CE) coupled with a photodiode array detector. Application of pressure during CE analysis allowed completion of one CE run in less than 1 min, and the obtained pH-metric