A rapid method for pKa determination of
✍
Yasushi Ishihama; Masahiro Nakamura; Toshinobu Miwa; Takashi Kajima; Naoki Asaka
📂
Article
📅
2002
🏛
John Wiley and Sons
🌐
English
⚖ 152 KB
👁 1 views
We developed a rapid screening method for determination of pK(a) of candidate drugs by pressure-assisted capillary electrophoresis (CE) coupled with a photodiode array detector. Application of pressure during CE analysis allowed completion of one CE run in less than 1 min, and the obtained pH-metric