The assessment of sample size in clinical trials comparing population means requires a variance estimate of the main efficacy variable. When this variance estimate has a low precision, it may be appropriate to use the data from the first patients entered in the trial ('internal pilot study') to esti
Internal pilots for observational studies
β Scribed by Matthew J. Gurka; Christopher S. Coffey; Kelly K. Gurka
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 166 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0323-3847
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The two-stage design involves sample size recalculation using an interim variance estimate. Stein proposed the design in 1945; biostatisticians recently have shown renewed interest in it. Wittes and Brittain proposed a modiΓΏcation aimed at greater e ciency; Gould and Shih proposed a similar procedur
## Abstract This is a discussion of the paper' Sample size recalculation in internal pilot study designs' by Tim Friede and Meinhard Kieser, appearing in this special issue on adaptive designs. (Β© 2006 WILEYβVCH Verlag GmbH & Co. KGaA, Weinheim)