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Internal cavities and buried waters in globular proteins

✍ Scribed by Rashin, Alexander A.; Iofin, Michael; Honig, Barry


Book ID
121342238
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
865 KB
Volume
25
Category
Article
ISSN
0006-2960

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## Abstract The solvent accessible surface area (SASA) algorithm is conventionally used to characterize protein surfaces in electrostatic energy computations of proteins. Unfortunately, it often fails to find narrow cavities inside a protein. As a consequence p__K__~a~ computations based on this al