Intermolecular and intramolecular phenol phenylation:Regioselective synthesis of unsymmetrically substituted biphenyls and 9,10-dihydrophenanthrenes

✍ Scribed by T. Caronna; F. Ferrario; S. Servi

• Book ID: 104237581
• Publisher: Elsevier Science
• Year: 1979
• Tongue: French
• Weight: 176 KB
• Volume: 20
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)86029-9

✦ Synopsis

Organic molecules containing as subunits biphenyl groupings or dihydrophenanthrenes skeletons, are very common in nature and many classes of biologically active natural products, have a similar structure. It has been widely recognised that often the formation of the phenyl -phenyl bond in such molecules, constitutes the crucial step in the synthetic pathway, and many studies have been devoted to the solution of this synthetic problem 192 .

Pschorr type reactions and oxydative phenol coupling 2-9 , are the route most couuaonly involved in such synthesis.