Intermittent Blood Flow in Solid Tumours – an under-appreciated Source of ‘drug Resistance’

Oestrogen potentiates topoisomerase-II-m

Oestrogen potentiates topoisomerase-II-mediated cytotoxicity in an activated subpopulation of human breast cancer cells: Implications for cytotoxic drug resistance in solid tumours

✍ R. J. Epstein; P. J. Smith; J. V. Watson; C. Waters; N. M. Bleehen 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 811 KB

Primary resistance to chemotherapeutic agents is a major problem in the management of advanced cancer. By using oestrogen to modulate the topoisomerase II content of T-47D human breast cancer cells, we show here that cell subpopulations resistant to the topoisomerase-ll-interactive drug VP 16 (etopo