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Interleukins (IL)-1 and IL-2 control IL-2 receptor α and β expression in immature thymocytes

✍ Scribed by Anne Wilsonu; Patricia Corthésyu; Patrick Reichenbachu; H. Robson MacDonaldu; Markus Nabholz

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
909 KB
Volume
24
Category
Article
ISSN
0014-2980

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✦ Synopsis

Interleukins (1L)-1 and IL-2 control IL-2 receptor - a and p expression in immature thymocytes" Functional high-affinity interleukin-2 receptors (IL-2R) contain three transmembrane proteins, IL-2Ra, p and y. We have investigated the expression of IL-2Ra and 0 genes in immature mouse thymocytes. Previous work has shown that during differentiation these cells transiently express IL-2Ra on their surface. Stimulation of IL-2Ra+ and IL-2Ra-immature thymocytes with phorbol 12-myristate 13-acetate and calcium ionophore induces synthesis of IL-2Ra and IL-2RP mRNA. Most of this response depends on autocrine stimulation by IL-2. IL-1 synergizes with IL-2 to induce a 120-fold increase in IL-2Ra mRNA and a 14-fold increase in IL-2RP mRNA levels. A large proportion of the stimulated cells contains both transcripts. These interleukins do not induce any differentiation to more mature phenotypes. Collectively, these results show that IL-2 plays a major role in the regulation of IL-2R expression in normal immature thymocytes. We suggest that this response to interleukins may be part of a homeostatic mechanism to increase the production of immature thymocytes during stress.

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