## Abstract Amyloid precursor protein (APP) has been characterized as an adipocyte‐secreted protein that might contribute to obesity‐related insulin resistance, inflammation, and dementia. In the current study, regulation of APP by the proinflammatory and insulin resistance‐inducing cytokine tumor
✦ LIBER ✦
Interleukin-6 is a positive regulator of tumor necrosis factor α-induced adipose-related protein in 3T3-L1 adipocytes
✍ Scribed by Mathias Fasshauer; Susan Kralisch; Margit Klier; Ulrike Lossner; Matthias Bluher; Anne-Marie Chambaut-Guérin; Johannes Klein; Ralf Paschke
- Book ID
- 117106273
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 156 KB
- Volume
- 560
- Category
- Article
- ISSN
- 0014-5793
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The role(s) of protein kinases in the regulation of G protein-dependent activation of phosphatidylinositolspecific phospholipase C by tumor necrosis factor-alpha was investigated in the osteoblast cell line MC3T3-E1. We have previously reported the stimulatory effects of tumor necrosis factor-alpha