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Interleukin-6 involvement in brain arteriovenous malformations

✍ Scribed by Yongmei Chen; Ludmila Pawlikowska; Jianhua S. Yao; Fanxia Shen; Wenwu Zhai; Achal S. Achrol; Michael T. Lawton; Pui-Yan Kwok; Guo-Yuan Yang; William L. Young

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
665 KB
Volume
59
Category
Article
ISSN
0364-5134

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## Abstract Interleukin (IL)‐6 is a pleiotropic cytokine whose production by astrocytes in the CNS of transgenic mice (termed GF‐IL6) causes neuroinflammation and neurodegeneration. The binding of IL‐6 to its receptor (IL6R) triggers gp130‐mediated activation of STAT1 and STAT3 as well as SHP2 phos