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Interleukin-6 and Interleukin-1 enhancement of GM-CSF-dependent proliferation of haematopoietic progenitor cells in myelodysplastic syndromes

โœ Scribed by Martin R. Schipperus; Pieter Sonneveld; Jan Lindemans; Kirsten van Lom; Margreet Vlastuin; Johannes Abels

Book ID
114712703
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
639 KB
Volume
77
Category
Article
ISSN
0007-1048

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Growth regulation of the AML-193 leukemi
Growth regulation of the AML-193 leukemic cell line: Evidence for autocrine production of granulocyte-macrophage colony-stimulating factor (GM-CSF), and inhibition of GM-CSF-dependent cell proliferation by interleukin-1 (IL-1) and tumor necrosis factor (tnfฮฑ)
โœ Vincent Kindler; John Shields; Dominique Ayer; Gonzalo J. Mazzei ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 583 KB

The human leukemic cell line AML-193 was tested for its proliferative response to endogenously produced autocrine factors and to a variety of cytokines and colony-stimulating factors. Cells grown in the absence of GM-CSF incorporated tritiated thymidine, and this was partially reversed by adding neu