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Interleukin 4 is at 5q31 and interleukin 6 is at 7p15

✍ Scribed by Grant R. Sutherland; Elizabeth Baker; David F. Callen; Valentine J. Hyland; Gordon Wong; Steven Clark; Simon S. Jones; Lisa K. Eglinton; M. Frances Shannon; Angel F. Lopez; Mathew A. Vadas

Book ID
104702957
Publisher
Springer
Year
1988
Tongue
English
Weight
256 KB
Volume
79
Category
Article
ISSN
0340-6717

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✦ Synopsis

DNA probes to the human interleukin 4 (IL4) and interleukin 6 (IL6) genes have been used for in situ hybridization to normal human chromosomes and Southern blot analysis of a series of mouse-human hybrid cell lines. IL4 maps to 5q31, the same location as IL5 and other haemopoietic growth factor genes. IL6 maps to 7p15. The significance of these locations is discussed.

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A DNA probe for the interleukin-7 receptor gene was used for in situ hybridisation and Southern blot analysis of a series of rodent-human hybrid cell lines. The IL-7 receptor gene maps to 5p13.