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Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo

✍ Scribed by Olver, Stuart; Apte, Simon H.; Baz, Adriana; Kelso, Anne; Kienzle, Norbert

Book ID
121274533
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
462 KB
Volume
139
Category
Article
ISSN
0019-2805

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## Abstract 4‐1BBL^–/–^ mice have a defect in recall CD8^+^ T cell responses to viruses, whereas CD4^+^ T cell responses to virus are unimpaired in these mice. In contrast, both CD4^+^ and CD8^+^ T cells respond to 4‐1BB ligand (4‐1BBL) __in vitro__. To clarify the role of 4‐1BB/4‐1BBL in CD4^+^ ve