Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation
✍ Scribed by Michael Finney; Graeme R. Guy; Robert H. Michell; John Gordon; Bernard Dugas; Kevin P. Rigley; Robin E. Callard
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 690 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Interleukin 4 signaling in human B cell Interleukin 4 activates human B lymphocytes transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation 151 via
We report from three independent centers that, in human tonsillar B lymphocytes, human IL4 switches on a series of second messenger changes, the precise sequence of which constitutes a novel signal transduction cascade. It involves an immediate and transient elevation of inositol1,4,5-trisphosphate and Ca2+ levels. This is followed several minutes later by a sustained rise in cellular cyclic adenosine monophosphate concentration, the triggering of which involves both the Ca2+ rise and an additional, as yet unidentified, IL4-generated signal. Both the products of the initial inositol lipid hydrolysis and the delayed cyclic adenosine monophosphate accumulation are essential for the later induction of CD23 expression, a major phenotypic change promoted in these cells by IL4. The striking contrast between these findings and those that have been observed for the IL 4 triggering of murine B cells is discussed.