Bone marrow-derived mesenchymal stem cells (MSCs) have therapeutic potential in liver injury, but the signals responsible for MSC localization to sites of injury and initiation of differentiation are not known. Adenosine concentration is increased at sites of cellular injury and inflammation, and ad
Interleukin-3 induces hepatocyte-specific metabolic activity in bone marrow-derived liver stem cells
β Scribed by Daniel Inderbitzin; Itzhak Avital; Adrian Keogh; Guido Beldi; Mattia Quarta; Beat Gloor; Daniel Candinas
- Book ID
- 108137546
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 132 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1091-255X
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## Abstract ## Background Bone marrowβderived liver stem cells (BDLSCs) are very robust cells that can differentiate into liver epithelial cells. These stem cells are promising targets for gene therapy treatment of liver diseases. Liver fibrosis results from chronic liver damage characterized by a
Adult bone marrow-derived mesenchymal stem cells (MSCs) exist in all living species and are capable of differentiating into different types of specific cells. In this study, we demonstrate the therapeutic effectiveness of rat MSC transplantation in D-galactosamine (GalN)-induced acute liver injury a