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Interleukin-2–activated natural killer cells can induce both apoptosis and necrosis in rat hepatocytes

✍ Scribed by W. Marty Blom; Hans J. G. M. De Bont; Irma Meijerman; Peter J. K. Kuppen; Gerard J. Mulder; J. Fred Nagelkerke

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
286 KB
Volume
29
Category
Article
ISSN
0270-9139

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## Abstract The proteasome is a multi‐subunit protease complex that is involved in intracellular protein degradation in eukaryotes. Previously, we have reported that selective, synthetic chymotryptic proteasome inhibitors inhibit A‐NK cell‐mediated cytotoxicity by approximately 50%; however, the ex