Interleukin-23: Linking Mesenteric Lymph Node Dendritic Cells With Th1 Immunity in Crohn's Disease
β Scribed by Maria Rescigno; Iliyan D. Iliev
- Book ID
- 119761194
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 755 KB
- Volume
- 137
- Category
- Article
- ISSN
- 0016-5085
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Background: Tumor necrosis factor (TNF)-like protein 1A (TL1A) is a member of the TNF superfamily and contributes to the pathogenesis of Crohn's disease (CD) by stimulating T-helper (Th) 1 cells. In addition to Th1, recent studies have focused on the role of Th17 cells in the pathogenesis of CD. Her
## Background: We analyzed the influence of Crohn's disease (CD)associated IL23R gene variants on IL-22 that is expressed in IL-23RΟ© Th17 cells. Methods: IL-22 serum levels were measured in 242 CD patients and in 31 healthy controls. Subanalyses included serum levels of IL-6, TNF-β£, IL-17A, IL-17