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Interleukin-23: A central cytokine in the pathogenesis of spondylarthritis

✍ Scribed by J. S. Hill Gaston; Jane C. Goodall; Dominique Baeten


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
116 KB
Volume
63
Category
Article
ISSN
0004-3591

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Objective. HLA-B27 is implicated in the pathogenesis of spondylarthritis (SpA), yet the molecular mechanisms are incompletely defined. HLA-B27 misfolding has been associated with endoplasmic reticulum stress and activation of the unfolded protein response (UPR) in macrophages from HLA-B27/human ␀ 2