Overexpression of cyclooxygenase (COX)-2 has been implicated in the development of cancer. This study aimed to evaluate the relationship between genetic variants in COX-2 promoter interacting with Helicobacter pylori and the susceptibility to gastric cancer (GC). Three COX-2 polymorphisms -1290A>G (
Interleukin-2 Gene Polymorphisms Associated with Increased Risk of Gastric Atrophy from Helicobacter pylori Infection
โ Scribed by Shozo Togawa; Takashi Joh; Makoto Itoh; Nobuyuki Katsuda; Hidemi Ito; Keitaro Matsuo; Kazuo Tajima; Nobuyuki Hamajima
- Book ID
- 111668477
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 111 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1083-4389
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We conducted a longitudinal cohort study to determine the association of Helicobacter pylori infection and the progression of chronic atrophic gastritis (CAG) with gastric cancer. A cohort of 4655 healthy asymptomatic subjects was followed for a mean period of 7.7 years. H. pylori infection was esta
## Abstract Several polymorphisms of the __IL1B__ and __IL10__ gene promoters have been reported to be associated with gastric cancer risk in Caucasians. However, studies in other populations have shown differing results. We aimed to test for associations between polymorphisms in __IL1B__ (__โ31__