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Interleukin-1β-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression

✍ Scribed by Jager, Jennifer; Grémeaux, Thierry; Cormont, Mireille; Le Marchand-Brustel, Yannick; Tanti, Jean-François

Book ID
127079501
Publisher
Endocrine Society
Year
2007
Tongue
English
Weight
447 KB
Volume
148
Category
Article
ISSN
0013-7227

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Previously, we reported that insulin-stimulated glucose uptake (ISGU) can be inhibited by endothelin (ET-1). However, the mechanism by which ET-1 impairs ISGU in adipocytes remains unclear. This study investigated the effects of ET-1 on insulin action in rat adipocytes in order to elucidate the mole