Interleukin 1β-induced inhibition of gastric acid secretion involves glutamate, NO and cGMP synthesis in the brain

Increased expression of mRNA encoding in

Increased expression of mRNA encoding interleukin-1β and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration

✍ Charlotta Eriksson; Roya Tehranian; Kerstin Iverfeldt; Bengt Winblad; Marianne S 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 427 KB 👁 1 views

Kainic acid, an analogue of glutamate, injected systemically to rats evokes seizures that are accompanied by nerve cell damage primarily in the limbic system. In the present study, we have analyzed the temporal profile of the expression of the cytokines interleukin-1␤ (IL-1␤) and IL-1 receptor antag