Interleukin-18 genetics and inflammatory disease susceptibility
β Scribed by Thompson, S R; Humphries, S E
- Book ID
- 110037870
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 145 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1466-4879
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## Background: Interleukin-18 (il-18) is increased in the inflamed mucosa of patients with crohn's disease (cd). the balance between this pleiotropic proinflammatory cytokine and its natural inhibitor, il-18-binding protein (il-18bp), may contribute to the pathogenesis of inflammatory bowel disease
## Abstract Interleukinβ18 (ILβ18)β656T/G, β607A/C, and β137C/G promoter polymorphisms had been reported associated with Kawasaki disease (KD). An ILβ18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma, rheumatoid, and systemic lupus erythematosus. We tested a