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Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes

✍ Scribed by Judith Sylvester; Abdelhamid Liacini; Wen Qing Li; Muhammad Zafarullah

Book ID
113527572
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
661 KB
Volume
16
Category
Article
ISSN
0898-6568

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## Abstract Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM) synthesis. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is located in ECM and is the major inhibitor of matrix metalloproteinases (MMPs) and aggrecanase,