✦ LIBER ✦
Interleukin 17: An example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis
✍ Scribed by Paul Schwarzenberger; Jay K. Kolls
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 138 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0730-2312
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✦ Synopsis
Interleukin 17 (IL-17) is an essential proinflammatory T-cell derived cytokine with various biological actions. IL-17 was found to have a pivotal role in microbial host defense by interconnecting lymphoid and myeloid host defense. It also acts as a stimulatory hematopoietic cytokine by expanding myeloid progenitors and initiating proliferation of mature neutrophils. This article summarizes results to date on IL-17 research and discusses gene therapy based strategies that were employed to determine its biological functions and significance. A comprehensive working model for IL-17 is introduced.