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Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis

✍ Scribed by Tineke Van Veen; J. Bart A. Crusius; Hans M. Schrijver; Gerd Bouma; Joep Killestein; Lisa Van Winsen; A. Salvador Peña; Chris H. Polman; Bernard M.J. Uitdehaag

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
116 KB
Volume
50
Category
Article
ISSN
0364-5134

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✦ Synopsis

In their article on herpes simplex virus type 1 (HSV-1) infection and acute retinal necrosis (ARN), Maertzdorf and colleagues 1 report that the HSV-1 strains in brain and eye of 2 patients with ARN following an episode of HSV encephalitis were genotyped, and strains in both brain and eye were identical in each patient. They conclude that their results indicate brain-to-eye transmission of HSV-1 in patients. Fig. Cumulative survival curve for G93A SOD1 mice with or without targeted iNOS allele deletions. There is no significant difference in survival between the differing genotypes. SOD ϭ G93A SOD1.

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The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: Critical role of interleukin-12p40
✍ Nozomi Takahashi; Victor C. L. de Jager; Anton Glück; Martin Letzkus; Nicole Har 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 516 KB

## Abstract ## Objective Repeated injection of streptococcal cell wall (SCW) fragments results in chronic arthritis in mice. The objective of this study was to identify genes and pathways that determine disease progression based on gene expression profiling in this model. ## Methods Chronic arth