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Interleukin-12: Role of Interferon-γ in IL-12 Adverse Effects

✍ Scribed by Bernhard Ryffel


Book ID
112240946
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
65 KB
Volume
83
Category
Article
ISSN
1090-2341

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IL-18 (interferon-inducing factor) and IL-12 exhibit a marked synergism in interferon-gamma induction in T cells. Investigations into the mechanism of this synergism have revealed that IL-12 upregulates expression of the IL-18 receptor on cells producing interferon-gamma. Although IL-18 does not ind