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Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia

✍ Scribed by Claire Pouplard; Pascale Cornillet-Lefebvre; Redha Attaoua; Dorothée Leroux; Carinne Lecocq-Lafon; Jérôme Rollin; Florin Grigorescu; Philippe Nguyen; Yves Gruel


Book ID
116914887
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
534 KB
Volume
129
Category
Article
ISSN
0049-3848

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Recent reports indicate that antibodies associated with heparin-induced thrombocytopenia and thrombosis (HITP) are specific for complexes formed between heparin and the heparin-binding, platelet alpha granule protein, platelet factor 4 (PF4). As with other disorders mediated by immune complexes (IC)