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Interleukin-1 β induces cyclooxygenase through activation of mitogen-activated protein kinases and NFkB in rat neonatal cardiomyocytes: a cytoprotective effect


Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
237 KB
Volume
170
Category
Article
ISSN
1863-4362

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## Abstract ## Objective Mitogen‐activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP‐1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)