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Interleukin-1 stimulation of arachidonic acid release from human synovial fibroblasts; blockade by inhibitors of protein kinases and protein synthesis

✍ Scribed by Laura A. Cisar; Richard J. Schimmel; Eugene Mochan


Book ID
113388416
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
906 KB
Volume
3
Category
Article
ISSN
0898-6568

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## Abstract Hyaluronan accumulation in the retroorbital connective tissue is one of the pathological features of Graves' ophthalmopathy. Interleukin‐1Ξ² (IL‐1Ξ²) is known to stimulate hyaluronan synthesis in orbital fibroblasts. In the present study, the intracellular signal transduction pathways inv