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Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

✍ Scribed by Rosoff, Philip M.; Savage, Nerina; Dinarello, Charles A.

Book ID: 123116119
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 857 KB
Volume: 54
Category: Article
ISSN: 0092-8674
DOI: 10.1016/0092-8674(88)90181-X

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Sn-l,2-diacylglycerols (DAG) and ionized-free calcium can act as intracellular second messengers for cell activation. Traditionally, T-lymphocyte activation is assessed by measurements of DNA synthesis or lymphokine production, but these responses require several days to occur and involve multiple i