Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations
β Scribed by Clark, Simon R; McMahon, Catherine J; Gueorguieva, Iva; Rowland, Malcolm; Scarth, Sylvia; Georgiou, Rachel; Tyrrell, Pippa J; Hopkins, Stephen J; Rothwell, Nancy J
- Book ID
- 110046899
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 146 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0271-678X
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π SIMILAR VOLUMES
At relatively high protein concentrations (i.e., up to 100 mg/mL), recombinant human interleukin-1 receptor antagonist (rhIL-1ra) was found to exist in a monomer-dimer equilibrium controlled by solution ionic strength. Sedimentation equilibrium at 25 degrees C was used to measure the increase in the
At high protein concentrations (i.e., 50-100 mg/mL) and 378C, low solution ionic strength accelerates aggregation of recombinant human interleukin-1 receptor antagonist (rhIL-1ra). We have used a variety of physical and spectroscopic techniques to explain this observation. A population balance model