Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid

Enhanced susceptibility of S-100B transg

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human β-amyloid

✍ Jeffrey M. Craft; D. Martin Watterson; Alexander Marks; Linda J. Van Eldik 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 400 KB

## Abstract S‐100B is an astrocyte‐derived protein that is increased in focal areas of the brain most severely affected by neuropathological changes in Alzheimer's disease (AD). Cell‐based and clinical studies have implicated S‐100B in progression of a pathologic, glial‐mediated pro‐inflammatory st