Interleukin-1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts

✍ Scribed by David J. Hall; Clare Brownlee; Charles D. Stiles

• Book ID: 102883308
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 587 KB
• Volume: 141
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041410123

✦ Synopsis

Interleukin-1 alpha and beta are polypeptide hormones with a broad range of biological activities. Both interleukins are recognized by a receptor that has been chardcterized as a member of the immunoglobin superfamily. The interleukin-1 receptor does not appear to be a tyrosine protein kinase. Moreover, the intracellular events that mediate the multiple interleukin-1 responses are poorly understood. Here we show that the JE and KC genes, first isolated and characterized as platelet-derived growth factor inducible in quiescent BALBIc-3T3 fibroblasts, are induced by femtomolar concentrations of recombinant interleukin-1 alpha (rlL-1). The response of JE and KC to IL-1 occurs at the transcriptional Icvel. These observations suggest that an analysis of the JE and KC transcriptional response to rlL-l may aid in identifying elements involved in interleukin-1-mediated signal transduction.