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Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist–deficient mice

✍ Scribed by Marije I. Koenders; Isabel Devesa; Renoud J. Marijnissen; Shahla Abdollahi-Roodsaz; Annemieke M. H. Boots; Birgitte Walgreen; Franco E. di Padova; Martin J. H. Nicklin; Leo A. B. Joosten; Wim B. van den Berg


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
301 KB
Volume
58
Category
Article
ISSN
0004-3591

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## Abstract ## Objective To examine the capacity of T cell interleukin‐17A (IL‐17A; referred to hereinafter as IL‐17) to induce cartilage damage during experimental arthritis in the absence of IL‐1. ## Methods Local IL‐17 gene transfer was performed in the knee joint of IL‐1–deficient mice and w