Interleaved water and fat imaging and applications to lipid quantitation using the gradient reversal technique
✍ Scribed by Haiying Tang; Ed X. Wu; Richard Kennan; Haiying Liu; Donald S. Williams
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 521 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Purpose
To implement and evaluate the gradient reversal‐based chemical shift imaging technique to obtain qualitative and quantitative spatially‐registered fat and water images with high imaging efficiency at very high field.
Materials and Methods
A multiecho gradient reversal‐based sequence allowing interleaved water–fat imaging during a single acquisition and quantitation of fat/water content is presented. The sequence was optimized and implemented at 11.7T. The quantitation was verified with water–fat phantoms and applied to lipid measurement in an in vivo mouse model.
Results
Results from phantoms, in vivo lipid measurement in mouse liver and hind limb muscle, and ex vivo rat knee imaging experiments demonstrated the robustness and high selectivity of this technique for interleaved and quantitative water and fat imaging at very high field.
Conclusion
The proposed MRI technique permits interleaved water and fat imaging, with which spectrally well‐separated water and fat images at the identical slice locations could be obtained in a single acquisition without increasing scan time. The technique could be used for in vivo quantitative mapping of lipid content and applied to investigations using small animal experiment models. J. Magn. Reson. Imaging 2007;26:1064–1070. © 2007 Wiley‐Liss, Inc.