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Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes

โœ Scribed by C. Transon; S. Lecoeur; T. Leemann; P. Beaune; P. Dayer


Publisher
Springer
Year
1996
Tongue
English
Weight
127 KB
Volume
51
Category
Article
ISSN
0031-6970

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Bufuralol, debrisoquine, and dextromethorphan are three prototype substrates of the common genetic deficiency of oxidative drug metabolism in man known as debrisoquine/sparteine-type polymorphism. We describe assays for the in vitro metabolism of (+)-and (-)-bufuralol, debrisoquine, and dextromethor