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Intergenic Transcription and Developmental Remodeling of Chromatin Subdomains in the Human β-globin Locus

✍ Scribed by Joost Gribnau; Karin Diderich; Sara Pruzina; Roberta Calzolari; Peter Fraser

Book ID: 117736397
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 335 KB
Volume: 5
Category: Article
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(00)80432-3

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## Abstract We present a molecular model of eukaryotic gene transcription. For the β‐globin locus, we hypothesise that a transcription machine composed of multiple RNA polymerase II (PolII) assembles using the locus control region as a foundation. Transcription and locus remodelling can be achieved