Twenty-eight patients with chronic active hepatitis without cirrhosis who were positive for hepatitis B surface antigen and antibody to hepatitis B e antigen were followed for 1 to 15 years (mean 6.6 years) and underwent follow-up biopsy. At presentation, 12 of the 28 patients (43%) had hepatitis B
Interferon/long-term lamivudine combination therapy in anti-HBe positive chronic hepatitis B patients
โ Scribed by NIKOLAOS L NIKOLAIDIS; OLGA I GIOULEME; KONSTANTINOS A TZIOMALOS; ADAMOS S SAVERIADIS; NIKOLAOS GRAMMATIKOS; PANAGIOTIS DOUKELIS; ANASTASIOS D VOUTSAS; THEMISTOKLIS VASSILIADIS; KALLIOPI PATSIAOURA; ELENI ORFANOU-KOUMERKERIDOU; AIKATERINI BALASKA; NIKOLAOS P EUGENIDIS
- Book ID
- 108950475
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 64 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0815-9319
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One year of lamivudine treatment results in increased hepatitis B e antigen (HBeAg) seroconversion and serum hepatitis B virus (HBV) DNA negativity in children with chronic hepatitis B and high serum alanine aminotransferase concentrations. Two hundred seventy-six children who participated in a 1-ye
Anti-HBe-positive patients with precore mutants may have severe, progressive liver disease. Therapy with interferon has been effective, but relapses are frequent. To evaluate and compare two antiviral treatments, lymphoblastoid interferon fly-IFN) and adenine arabinoside 5'-monophosphate (ARA-AMP),
We have previously demonstrated that combination peginterferon and lamivudine treatment has superior antiviral efficacy to lamivudine monotherapy in chronic hepatitis B. In this study, we investigated the long-term posttreatment virological response to this combination treatment. Sustained virologic