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Interferon-γ therapy: Evaluation of routes of administration and delivery systems

✍ Scribed by Husam M. Younes; Brian G. Amsden

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
200 KB
Volume
91
Category
Article
ISSN
0022-3549

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✦ Synopsis

Although different routes and delivery systems have been used to deliver interferon-g (IFN-g) for the treatment of a variety of viral and neoplastic diseases, little has been reported regarding the most ef®cient and least toxic routes and drug delivery modes required to achieve these goals. To have a greater understanding of the best strategies to use to administer this cytokine in an ef®cient, stable, and safe manner, this review details aspects of IFN-g concerning its mechanism of action, physical properties, and pharmacokinetics. One important conclusion that is drawn from this analysis is that a consistent, local concentration of IFN-g is necessary to achieve an optimal therapeutic response. A critical discussion covering the advantages and limitations of the currently used methodologies to deliver IFN-g in such a fashion is presented. ß 2002

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