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Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO)

✍ Scribed by Croitoru-Lamoury, Juliana; Lamoury, Francois M. J.; Caristo, Michael; Suzuki, Kazuo; Walker, David; Takikawa, Osamu; Taylor, Rosanne; Brew, Bruce J.; Ikezu, Tsuneya

Book ID
120189508
Publisher
Public Library of Science
Year
2011
Tongue
English
Weight
766 KB
Volume
6
Category
Article
ISSN
1932-6203

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## Abstract Indoleamine 2,3‐dioxygenase (IDO), a tryptophan‐catabolizing enzyme, is an intracellular enzyme possessing various immunosuppressive properties. Here, we report the possible use of this enzyme to suppress proliferation of immune cells cocultured with IDO‐expressing fibroblasts of an all