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Interferon-γ Receptor-1 Gene Promoter Polymorphisms (G-611A; T-56C) and Susceptibility to Tuberculosis

✍ Scribed by L. Bulat-Kardum; G. E. Etokebe; J. Knezevic; S. Balen; N. Matakovic-Mileusnic; L. Zaputovic; J. Pavelic; Z. Beg-Zec; Z. Dembic


Book ID
110861243
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
120 KB
Volume
63
Category
Article
ISSN
0300-9475

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Genetic differences in the metabolism of carcinogens may codetermine individual predisposition to cancer. Cytochrome P-4501A1 (CYP1A1) metabolically activates precarcinogens in cigarette smoke, such as benzo(a)pyrene, which is also an inducer of CYP1A1. Two point mutations have been reported, ml in