Interferon-γ-Like immunoreactivity in sensory neurons may influence the replication of sendai and mumps viruses
✍ Scribed by A. Eneroth; T. Andersson; T. Olsson; C. Örvell; E. Norrby; K. Kristensson
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 699 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0360-4012
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✦ Synopsis
Rat dorsal root ganglia in tissue culture, which contain an interferon-y (IFN-?)-like immunoreactive subpopulation of neurons, were infected with paramyxoviruses. Sendai virus caused a substantial neuronal lysis, while the RW strain of mumps virus caused a much less pronounced nerve cell loss. Early during infection, the subpopulation of IFN-y-like immunoreactive neurons was less susceptible to mumps virus. Virus antigen was rapidly lost from surviving IFN-y-like positive neurons infected with Sendai virus, while this remarkable self-curing effect occurred in both nerve cell populations at later time points after mumps virus infection. By quantitative enzymelinked immunosorbent assay (ELISA) technique, increased levels of "neuronal IFN-y" were recorded at 10 hr and 30 hr after infection with Sendai and mumps virus, respectively. This study indicates a role for the neuronal IFN-y-like molecule in determining the outcome of a viral infection in sensory ganglia.