Interferon-␥ (IFN-␥), a multifunctional cytokine produced by activated Th1 lymphocytes, exerts potent effects on the extracellular matrix by regulating fibroblast function. In this study, we examined the modulation of ␣1(I) procollagen gene (COL1A1) expression by recombinant IFN-␥. The results showe
✦ LIBER ✦
Interferon-γ inhibits the lipopolysaccharide-induced macrophage inflammatory protein-1α gene transcription in human neutrophils
✍ Scribed by Marco A. Cassatella
- Book ID
- 107908605
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 459 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0165-2478
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## Abstract PPARs and LXRs are ligand‐activated transcription factors that are emerging as promising therapeutic targets for limiting atherosclerosis, an inflammatory disorder orchestrated by cytokines. The potent anti‐atherogenic actions of these nuclear receptors involve the regulation of glucose