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Interferon-β therapy for malignant melanoma: the dose is crucial for inhibition of proliferation and induction of apoptosis of melanoma cells

✍ Scribed by Hitomi Kubo; Atsuko Ashida; Kazuhiko Matsumoto; Toshiro Kageshita; Akifumi Yamamoto; Toshiaki Saida


Book ID
106078820
Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
339 KB
Volume
300
Category
Article
ISSN
0340-3696

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## Abstract The synthetic retinoid fenretinide [N‐(4‐hydroxyphenyl)retinamide, 4‐HPR] has demonstrated growth inhibition and induction of apoptosis of various malignant cells, including lung cancer cell lines. 4‐HPR is now being investigated in several clinical trials. In our study, we show that 4‐