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Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox

✍ Scribed by Biron, Christine A.; Nguyen, Khuong B.; Cousens, Leslie P.; Doughty, Lesley A.; Pien, Gary C.; Durbin, Joan E.


Book ID
109828447
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
234 KB
Volume
1
Category
Article
ISSN
1529-2908

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Interferon α/β-mediated inhibition and p
✍ Biron, Christine A.; Nguyen, Khuong B.; Cousens, Leslie P.; Doughty, Lesley A.; 📂 Article 📅 2000 🏛 Nature Publishing Group 🌐 English ⚖ 234 KB

Induction of high systemic levels of type 1 interferons (IFNs) IFN-alpha and IFN-beta is a hallmark of many viral infections. In addition to their potent antiviral effects, these cytokines mediate a number of immunoregulatory functions and can promote IFN-gamma expression in T cells. However, during