Interferon-α mediates suppression of C-reactive protein: Explanation for muted C-reactive protein response in lupus flares?

Lack of clinical evidence for involvemen

Lack of clinical evidence for involvement of hepatitis C virus interferon-? sensitivity-determining region variability in RNA-dependent protein kinase-mediated cellular antiviral responses

✍ Mihm, Sabine; Monazahian, Masyar; Grethe, Stefanie; Meier, Volker; Thomssen, Rei 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 426 KB 👁 2 views

The hepatitis C virus (HCV) interferon-␣ (IFN-␣) sensitivity-determining region (ISDR) has been shown to suppress double-stranded RNAdependent protein kinase (PKR) activity in vitro in a yeast PKR expression system. Since variability of ISDR was shown to correlate with nonresponsiveness to IFN-␣ the