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Interferon-α for chronic hepatitis C: An analysis of pretreatment clinical predictors of response

✍ Scribed by Luigi Pagliaro; Antonio Craxí; Calogero Cammaá; Fabio Tiné; Vito Di Marco; Oreste Lo Iacono; Piero Almasio

Book ID
102848735
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
868 KB
Volume
19
Category
Article
ISSN
0270-9139

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✦ Synopsis

To identify predictors -of short-term and sustained ALT normalization after interferon treatment in adult patients with chronic hepatitis C, we performed a metanalysis of individual patients' data, with construction and cross-validation of a prediction rule, in 361 patients from two randomized trials. In one trial, 116 subjects with transfusion-related chronic hepatitis C were treated with lymphoblastoid interferon (6 MU/m2 three times a week for 2 mo, then 3 MU/m2 three times a week for 4 or 10 mo). In the other study, 245 patients with community-acquired chronic hepatitis C received recombinant interferon-%, (10 MU three times a week for 2 mo, then 5 MU three times a week for 4 mo; then random allocation of subjects with

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