INTERFERON α AUGMENTS ACTIVATION-INDUCED T CELL DEATH BY UPREGULATION OF FAS (CD95/APO-1) AND FAS LIGAND EXPRESSION
✍ Scribed by Arthur Kaser; Shigekazu Nagata; Herbert Tilg
- Book ID
- 115596321
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 280 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1043-4666
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CD95(APO-1/Fas) ligand (CD95L) gene expression is critically involved in activation-induced T cell apoptosis. We and other have previously shown that HIV-1 Tat which is essential for efficient HIV gene expression sensitizes CD95-mediated apoptosis and up-regulates CD95L expression in T cells. In the
CD95 (Apo-1/Fas) ligand (CD95L) expression has been observed in various malignancies. In human primary cell lines from a squamous cell carcinoma (SCC) of the vulva, the effect of cisplatin (CDDP) and IFN␥ on the expression of CD95L and its 2 receptor isoforms, CD95 transmembrane (CD95tm) and CD95 so