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Interferon-α accelerates murine systemic lupus erythematosus in a T cell–dependent manner

✍ Scribed by Zheng Liu; Ramalingam Bethunaickan; Weiqing Huang; Umairullah Lodhi; Ingrid Solano; Michael P. Madaio; Anne Davidson


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
377 KB
Volume
63
Category
Article
ISSN
0004-3591

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✍ Debjani Ghosh; Katalin Kis-Toth; Yuang-Taung Juang; George C. Tsokos 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 463 KB

## Abstract ## Objective T cells from patients with systemic lupus erythematosus (SLE) display increased amounts of spleen tyrosine kinase (Syk), which is involved in the aberrant CD3/T cell receptor–mediated signaling process, and increased amounts of CREMα, which suppresses the production of int