Interferon regulatory factor-1 directs the posttranslational modification and release of high mobility group box-1 in endotoxemia
β Scribed by Jon S. Cardinal; Pinhua Pan; Rajeeb Dhupar; Sung Cho; John Evankovich; David Geller; Allan Tsung
- Book ID
- 113679290
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 95 KB
- Volume
- 209
- Category
- Article
- ISSN
- 1072-7515
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Highβmobility group boxβ1 (HMGB1) was originally identified as a ubiquitously expressed, abundant nonhistone DNAβbinding protein. Recently, it was found to act as a cytokineβlike mediator of delayed endotoxin lethality and of acute lung injury. Previously, we reported that HMGB1 is mass
Physical interaction between the lymphoid high mobility group (HMG)-box architectural transcription factors TCF/ LEF and b-catenin is associated with translocation of the heteromeric complex to the nucleus and regulation of target gene expression. Since formation of molecular complexes among b-caten