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Interferon potentiates antiproliferative activity of CPT-11 against human colon cancer xenografts

โœ Scribed by Susumu Ohwada; Isao Kobayashi; Michio Maemura; Yoshihiro Satoh; Tetsushi Ogawa; Yuichi Iino; Yasuo Morishita


Book ID
117468373
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
515 KB
Volume
110
Category
Article
ISSN
0304-3835

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CPT-11 in human colon-cancer cell lines
โœ Willy J.M. Jansen; Bas Zwart; Saskia T.M. Hulscher; Giuseppe Giaccone; Herbert M ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 104 KB ๐Ÿ‘ 2 views

CPT-11, a new semisynthetic derivative of camptothecin, is active in a number of tumor types in the clinic, including colon cancer. CPT-11 is a drug that is converted into the active metabolite SN-38 by a carboxylesterase. Experiments were performed to obtain more insight in the cellular characteris